Biological Sensors
BEADS*: A Basic Tool for Bio-Detection (255)
Problem: Detect biological DNA, RNA, and protein signatures with high specificity and high sensitivity in dirty environments
*BEADS: Biodetection Enabling Analyte Delivery SystemProject Activity Scope (from Technical Overview Chart):
Mechanisms through Integrated Systems
PNNL Solution:
- Use micro-beads for automated analyte purification and concentration
- Micro-Beads provide high specificity collection, concentration, and separation of whole cells, proteins, or nucleic acids
- Employ transduction based on optical, mass or charge discrimination
Capabilities Employed to Meet Client Needs: Bead attachment chemistry; antibody development; renewal filter system development; bead handling methodologies; sample cell design for reliable bead exchange (rotating rod concept); fluidic systems; interface requirements to multiple sensor/detection technologies.
Selected Links to Related Information:
- Related Examples (Same Project)
- Renewable Chem-Bio Sensor System (409)
- BEADS for Selective Analyte Capture (407)
- Automated BEAD Suspension Arrays (254)
- Automated Fluidics for BEADS Sensors (411)
- Automated Toxin Detection System (412)
- BEADS Automated Immunoassays (259)
- BEADS: Automated Sample Processing System for Biodetection (260)
- Beads for Separations, Processing, Sensing (261)
- Nucleic Acid Extraction and Purification (408)
- "Reporters" Indicate Target Analyte Capture (410)
- Ultrasonic Biological Cell Disruption (258)
- Similar Technology Examples (Same or Different Application)
- Related Websites
- Breakthroughs, Winter/Spring 2002 (.pdf 7.3MB - see second item)
- BEADS (Biodetection Enabling Analyte Delivery System) Sample Preparation Technology
Contact: Cindy Bruckner-Lea
