Biological Sensors
BEADS for Selective Analyte Capture (407)
Problem: Selectively capture target species, either chemical or biological, for purification or detection.
Project Activity Scope (from Technical Overview Chart): Mechanisms through Sensors and Devices
PNNL Solution:
- Capture target species on small particles to allow manipulation
- Select particle type for specific application requirements (porous silica, magnetic or other particles)
- Treat surface of small particles to selectively capture target species (biological organisms; chemical species)
- Target species purification for biological applications
- Direct detection applications
Capabilities Employed to Meet Client Needs: Development of selective coatings for target analytes; surface functionalization; nano-beads and micro-beads used with renewable magnetic and non-magnetic bead-trapping flow cells for sensing applications; application of coatings to micro-beads for practical usage; development of automated fluidic systems for micro-bead and test solution manipulation; prototype component and subsystem design, fabrication, and evaluation; laboratory testing and validation with real-world complex samples; establish intellectual property position; publication of key results.
Selected Links to Related Information:
- Related Examples (Same Project)
- BEADS Automated Immunoassays (259)
- Enzyme Immobilization for Chem-Bio Sensors (288)
- Hand Held Biological Threat Detector (418)
- Imprinted Media for High Selectivity Sensors (238)
- Nanomaterials for Selective Preconcentration (271)
- Nucleic Acid Extraction and Purification (408)
- Renewable Chem-Bio Sensor System (409)
- Renewable Sensors for Chemical Detection (352)
- Related Websites
- Breakthroughs, Winter/Spring 2002 (.pdf 7.3MB - see second item)
- BEADS (Biodetection Enabling Analyte Delivery System) Sample Preparation Technology
