Biological Sensors
Renewable Chem-Bio Sensor System (409)
Problem: Need a reliable sensor system suitable for long-term detection of important chemicals and bio-organisms.
Project Activity Scope (from Technical Overview Chart): Mechanisms through Integrated Systems
PNNL Solution:
- Apply renewable sensor concept for extended use applications
- Use bead surface treatment to capture target analyte
- Use "reporters" to indicate analyte capture
- Automate fluidic system for independent operation
- Develop system for practical measurement of target analyte
- Demonstrate sensor approach is adaptable for measurement of important analytes
Capabilities Employed to Meet Client Needs: Bead attachment chemistry; antibody development; renewable filter system development; bead handling methodologies; sample bead-trap/flow-cell design for reliable bead exchange (rotating rod concept); system architecture; mesofluidics; renewable column technology; sample cell with magnetic column or rotating rod column for reliable sample exchange; interface requirements to multiple sensor/detection technologies. Integration with detection modalities (e.g., absorbance, fluorescence, electrochemical, etc.).
Selected Links to Related Information:
- Related Examples (Same Project)
- BEADS: A Basic Tool for Bio-Detection (255)
- Automated BEAD Suspension Arrays (254)
- Automated Fluidics for BEADS Sensors (411)
- Automated Toxin Detection System (412)
- BEADS: Automated Sample Processing System for Biodetection (260)
- BEADS for Selective Analyte Capture (407)
- BEADS for Separations, Processing, Sensing (261)
- Similar Application Examples (Same or Different Technology)
- Related Websites
- Breakthroughs, Winter/Spring 2002 (.pdf 7.3MB - see second item)
- BEADS (Biodetection Enabling Analyte Delivery System) Sample Preparation Technology
