Sensors & Electronics
Biological Sensors
Dual Array Method for Stress Analysis (447)
Problem: Measure environmental stress effect on messenger RNA population (+ or -) with minimal processing steps.
Project Activity Scope (from Technical Overview Chart): Mechanisms through Sensors and Devices.
PNNL Solution:
- Prepared 1st array to control sample
- Exposed 2nd array to test solution
- Analyzed each array
- Formed difference data array by subtracting corresponding pixel responses on the two arrays (i.e. [Responsex,y(Control) - Responsex,y(Test)])
- Pixel values indicate stress effects
Capabilities Employed to Meet Client Needs: Array preparation, hybridization, and data analysis.
Selected Links to Related Information:
- Related Examples (Same Project)
- Alternate Methods to Monitor Stress Effects (446)
- Concept for Two-Color Array Mechanism (449)
- Conceptual Introduction to DNA Basics (450)
- Detect Early Effects of Environmental Stress (444)
- Determine Sensitive Stress Indicator (445)
- DNA Array Basics (451)
- Organism Identification from Array Response (459)
- Tailored DNA Detector Array Preparation (457)
- Two-Color Array Method for Stress Analysis (448)
- Similar Application Examples (Same or Different Technology)
- Related Websites
- Microarrays: Chipping Away at the Mysteries of Science and Medicine — A Science Primer, National Center for Biotechnology Information, US National Institutes of Health, July 2007
Contact: Tim Straub
