Biological Sensors
Reagentless Detection of Biomolecules (376)
Problem: Need method for reagentless detection of multiple biological targets in field deployed situations.
Project Activity Scope (from Technical Overview Chart): Mechanisms through Instruments
PNNL Staff Solution*:
- Developed fiber optic sensor concept based on light interaction with biomaterials captured on fiber cladding
- Fabricated specialty grating-based fibers sensors to enhance interactions
- Coated optical fiber surfaces with films to selectively capture biological targets
- Integrated sensors with flow cells
- Demonstrated detection of small and large biomolecule targets
*Work performed during employment with Luna Innovations, Inc.
Capabilities Employed to Meet Client Needs: Establish instrument conceptual design, develop finite element model for light propagation characteristics, design optical fiber refractive profiles, construct UV-based fabrication facility based upon CW lasers, optimize sensitivity of sensing element through FEM modeling and empirical measurements, demonstrate coating chemistries to covalently attach selective films to optical fiber, design fluidic systems for sampling, develop signal processing algorithms, validate performance with pure and complex liquid-based samples.
Selected Links to Related Information:
- Related Examples (Same Project)
- Similar Technology Examples (Same or Different Application)
Contact: Mark Jones
