Biological Sensors
Ultrasonic Biological Cell Disruption (258)
Problem: Need to extract unique biomarkers from pathogenic spores to allow high specificity identification
Project Activity Scope (from Technical Overview Chart): Mechanisms through Sensors and Devices
PNNL Solution:
- Use ultrasonic disruption of difficult to penetrate spore coating to provide access to internal components and biomarkers
- Ultrasound is focused along the length of the flow path, for continuous processing
- Technique provides fast, low consumable approach to cell lysing and allows access to DNA, proteins and other components for biosensing
Capabilities Employed to Meet Client Needs: High frequency ultrasound; DNA analysis; protein biomarker analysis, micro-fluidics; bio-chemistry; BEADS system technology.
Selected Links to Related Information:
- Related Examples (Same Project)
- Automated BEAD Suspension Arrays (254)
- Automated Toxin Detection System (412)
- BEADS: A Basic Tool for Bio-Detection (255)
- BEADS Automated Immunoassays (259)
- BEADS: Automated Sample Processing System for Biodetection (260)
- BEADS for Selective Analyte Capture (407)
- Beads for Separations, Processing, Sensing (261)
- Nucleic Acid Extraction and Purification (408)
Contact: Cindy Bruckner-Lea
