Sensors & Electronics
Chemical Sensors
Chemical Exposure Biomarker Identification (363)
Problem: Need to determine if non-invasive biomonitoring can be used to effectively evaluate key chemical exposures
Project Activity Scope (from Technical Overview Chart): Mechanisms
PNNL Solution:
- Conducted animal exposure tests to evaluate chemical pesticide exposure evidence in body fluids obtained by invasive sampling (blood)
- Laboratory analytical measurements (GC/MS) established correlation between pesticide exposure and it's concentration in these body fluids
- Results also identified metabolic product of pesticide that may permit an alternative measurement option
Capabilities Employed to Meet Client Needs: Extraction of metabolite to isolate and eliminate contaminants, chemical derivatization to increase volatility, negative ion chemical ionization/GC/MS with selected ion monitoring for sensitivity and selectivity.
Selected Links to Related Information:
- Related Examples (Same Project)
- Similar Application Examples (Same or Different Technology)
- Related Websites
Contact: James Campbell
