Sensors & Electronics
Chemical Sensors
Biomarker Measurement in Saliva (364)
Problem: Need to determine if non-invasive biomonitoring can be used to effectively evaluate key chemical exposures
Project Activity Scope (from Technical Overview Chart): Mechanisms
PNNL Solution:
- Animal tests and PNNL-developed analytical methodology established pesticide and metabolic product levels in blood (invasive) and saliva (non-invasive)
- Pesticide was absent in saliva but the metabolite was present in saliva
- Demonstrated correlation of metabolite levels in blood and saliva indicating that saliva has the potential to be used as a non-invasive matrix to determine chemical exposure
- May be extended to other chemical exposures
Capabilities Employed to Meet Client Needs: Extraction of metabolite to isolate and eliminate contaminants, Chemical derivatization to increase volatility, Negative ion chemical ionization/GC/MS with selected ion monitoring for sensitivity and selectivity.
Selected Links to Related Information:
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Contact: James Campbell
