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Chemical Sensors

Breath Analysis for Chemical Exposure (304)

Problem: Need to rapidly and non-invasively determine the level of chemical exposure in humans and animals

Photo of scientist demonstrating breath analysis for chemical exposure equipment

Project Activity Scope (from Technical Overview Chart): Mechanisms through Instruments

PNNL Solution:

  • Exhaled breath analysis based on ion trap mass spectroscopy and physiologically based pharmacokinetic modeling
  • Field measurements can show toluene or benzene exposures as low as 1 ppb in humans
  • Sensitive to exposures from aerosols, liquids and solids

Capabilities Employed to Meet Client Needs: Animal modeling; toxicology, electrochemical sensors; micro-fluidics; statistical data analysis, physiologically based pharmacokinetic (PBPK) modeling; ion trap mass spectroscopy.

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Contact: Karla Thrall

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