Sensors & Electronics
Chemical Sensors
Non-Invasive Chemical Exposure Monitoring (362)
Problem: Need reliable, rapid, non-invasive measurement method to assess personal exposure to target chemicals.
Project Activity Scope (from Technical Overview Chart): Mechanisms through Instruments
PNNL Solution:
- Identify target chemical for non-invasive monitoring
- Utilize animal exposure, toxicology, pharmacokinetic modeling experience, analytical chemistry methods and instrumentation capabilities to identify exposure markers in primary body fluids
- Establish exposure indicator in non-invasive body fluids
- Utilize electrochemical experience to develop a sensor for non-invasive detection of chemical exposure as a viable option for rapid exposure monitoring
Capabilities Employed to Meet Client Needs: Animal exposure testing; high sensitivity laboratory chemical analysis of chemicals in body fluids; pharmacokinetic modeling of chemical exposure effects on animals; data analysis to determine exploitable chemical concentration effects in various fluids; selective material synthesis and fabrication for preconcentrator materials; electrochemical sensor and micro-fluidic component design and fabrication; system integration and demonstration for practical, rapid determination of chemical exposure using saliva as a non-invasive biomonitoring matrix; published results.
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Contact: Charles Timchalk
